Magic Mushrooms as an Anti-inflammatory

Psychedelics have recently been identified for their notable affiliation in treating many diseases; some of which include depression, anxiety and addiction. One of the newest additions to this list is the inclusion of magic mushrooms as an anti-inflammatory aid.

My, my, my…this is BIG news!

Inflammation can happen and has occurred to absolutely everyone. From athletes, to asthmatics, and even those of us who have been stung by a bee or even bumped our shin. The body naturally inflames when chaos ensues.

What is Inflammation?

Inflammation is the body’s natural response to injury and infection. It’s a vital part of the immune system signaling healing and repair to damaged tissues and the invasion of foreign bodies.

Inflammation symptoms can include: swelling, pain, redness, immobility and heat at the affected area.

Sometimes, in the case of disease, the body falsely activates inflammation triggers. Autoimmune disorders such as: rheumatoid arthritis, MS, and vasculitis are just a few that are paired with an inflammation of sorts.

Why Reduce Inflammation?

Whatever the case may be, external or internal inflammation, acute or chronic; sometimes long-term inflammation can cause more harm than good which is why its important to minimize exposure.

Cancer, depression, heart disease, diabetes, strokes and Alzheimer’s are all diseases that share a commonality…you guessed it…inflammation!

5-HT2A Receptor (Serotonin Receptor)

In efforts to not get too science-y on you, the 5-HT2A  natural receptor in the body is the gateway, if you will, in allowing magic mushrooms to work their…you guessed it…MAGIC.

Through the activation of a specific compound in magic mushrooms (R)-DOI or the long version: (R)-2,4-dimethoxy-4-iodoamphetamine, the 5-HT2A receptor is engaged.

Research groups suggest that the positive effects from psychedelic therapy, or better known as the use of magic mushrooms, resulted in a reduction of neuroinflammation.

Neuroinflammation is that of inflammation within the central nervous system (CNS). This includes areas such as the brain and spinal cord.

The even more exciting news is that the anti-inflammatory effects have demonstrated prevalence in pre-clinical trials far below the doses that would induce psychedelic effects.

This means, microdosing will allow the body to reap anti-inflammatory benefits without giving the patient a psychedelic trip which many initially think of when they hear “magic mushrooms.”

Anti-Inflammation Study

A study conducted by Charles Nichols, Ph.D. observed a reduction in aorta inflammation and a decrease in overall HDL cholesterol levels with the examination of the psychedelic compound (R)-DOI in relation to rats.

“Treatment with (R)-DOI significantly reduced pulmonary inflammation and improved airway function” according to Nichols.

Studies have also examined that inflammation as a result from asthma and other cardiovascular diseases have seen an improvement through the use of this drug in pre-clinical studies.

Magic Mushrooms as an Anti-Inflammatory

Magic mushrooms and their wonderfully complex compounds are being dissected and put to test in the name of health, wellness and prosperity. The “magic” these once negatively stigmatized fungi posses, is slowly unveiling itself.

Hello inflammation, please step aside, and allow magic mushrooms to stay.


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